Gene expression technologies
- Introduction to DNA microarrays. Microarrays in overview.
- Array fabrication. Preparation of labeled probes. Microarray hybridization.
- Reading methods. Imperfect data and noise.
- Generation and analysis of expression data. Normalization methods.
- SAGE, microplates, and differential display.
Seminar’s discussions
- Ink-jet spotting of arrays: Agilent
- What is noise?
- Affymetrix GeneChipTM glass slide experiments
Main reading
- P.S. Meltzer. Large-scale genome analysis // BIOINFORMATICS: A Practical Guide to the Analysis of Genes and Proteins / A.D. Baxevanis, B.F. Francis Ouellette – 2001 John Wiley & Sons, Inc. – P. 393-41
- DNA Microarrays : A Practical Approach / Edited by Mark Schena. - Oxford University Press, 1999.
Supplementary reading
- A Practical Approach to Microarray Data Analysis / Daniel P. Berrar ,Werner Dubitzky ,Martin Granzow. – Kluwer Academic Publishers, 2002
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