Lecture 12. Structural bioinformatics (24.05.2003)

    Structural bioinformatics
  1. Prinsiples of protein structure .
  2. Macromolecular structure determination by NMR spectroscopy.
  3. Molecular visualization.
  4. The PDB format, mmCIF formats and other data formats.
  5. Protein structure classification.
  6. Comparison of protein three-dimensional structures.
    Main reading
  1. C.W.V. Hogue. Structure databases // BIOINFORMATICS: A Practical Guide to the Analysis of Genes and Proteins / A.D. Baxevanis, B.F. Francis Ouellette – 2001 John Wiley & Sons, Inc. – P. 83-107.
  2. S. Banerjee-Basu, A.D. Baxevanis. Predictive methods using protein sequences // ibid. – P. 253-279.
  3. J. Heringa. Predicting secondary structure from protein sequences // ibid. – P. 133-141.
    Supplementary reading
  1. M.S. Johnson, J.V.Lehtonen. Comparison of protein three-dimensional structures // Bioinformatics: Sequence, Structure, and Databanks: A Practical Approach / Des Higgins (Editor), Willie Taylor (Editor). – Oxford University Press, 2002. – P. 15-50.

Internet Resources

Protein Data Bank at RCSB
RasMol
SwissPDB Viewer/Deep View
WebMol
AACompIdent
AACompSim
PROPSEARCH
DALI
Bryant-Lawrence
FSSP
UCLA-DOE
SWISS-MODEL
TOPITS